Kisspeptin

Kisspeptin

Product Format	10mg vials
Vial Size	10mg
Vial Capacity	3 mL
Box Combinations	20mg, 50mg, 100mg, 200mg
Cost per milligram	$3.83 – $6.00
Multi-vial Purity	99.713%
Endotoxin Screening	PASSED (<0.20 EU/mL)
Heavy Metals Screening	PASSED
Sterility Screening	PASSED
Independently Tested	YES

Peptide Partners Manufacturer Id: VI32

Batch Id: KSS2607

Notes: Five-vial batch average net content: 11.31 mg.

Overview

(For educational purposes only)

Kisspeptin-10 (KP-10) is the C-terminal 10-amino-acid fragment shared by the kisspeptin family and retains activity at the KISS1 receptor (KISS1R/GPR54). In laboratory research, it is used to investigate neuroendocrine signaling, receptor activation, intracellular calcium mobilization, MAP-kinase pathways, and cellular migration models. This product is supplied strictly for laboratory research use and is not intended for human or veterinary use.

Research Studies

(for educational purposes only)

Study 1: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54

Authors: Kotani M, Detheux M, Vandenbogaerde A, et al.

Source: The Journal of Biological Chemistry (2001) — PubMed

Scientific Findings

The investigators isolated kisspeptin peptides derived from KiSS-1 and identified them as low-nanomolar ligands for human and rat GPR54. Receptor activation induced phosphoinositide hydrolysis, calcium mobilization, MAP-kinase signaling, and other cellular responses.

Plain English Interpretation

A foundational receptor study establishing kisspeptins as the natural signaling molecules for GPR54 and mapping the downstream cellular response.

Study 2: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Authors: Ohtaki T, Shintani Y, Honda S, et al.

Source: Nature (2001) — PubMed

Scientific Findings

The study identified a 54-amino-acid KiSS-1-derived peptide, named metastin, as an endogenous ligand for hOT7T175/GPR54. Metastin inhibited chemotaxis and invasion in receptor-expressing cells in vitro and reduced pulmonary metastasis in a receptor-expressing mouse melanoma model.

Plain English Interpretation

A second foundational study linking the KiSS-1 peptide system to its receptor and to anti-migratory effects in cell and animal research models.

Study 3: The GPR54 gene as a regulator of puberty

Authors: Seminara SB, Messager S, Chatzidaki EE, et al.

Source: The New England Journal of Medicine (2003) — PubMed

Scientific Findings

Using human genetic studies, receptor-function assays, and a Gpr54-deficient mouse model, the investigators showed that loss-of-function GPR54 mutations disrupt gonadotropin-releasing hormone physiology and normal pubertal development.

Plain English Interpretation

This study established the kisspeptin receptor as an essential regulator of reproductive signaling and puberty in humans and mice.