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For Research Use Only. Not for Use in diagnostic procedures.

This product is solely intended for research purposes as a chemical compound. Its designation permits its use exclusively for in vitro testing and laboratory experimentation. All information regarding this product provided on our website is purely educational. By law, any form of bodily introduction of this product into humans or animals is strictly prohibited. It should only be handled by professionals who are licensed and qualified. This product is neither a drug, food, nor cosmetic, and must not be misrepresented, misused, or mislabeled as such.

DSIP

Delta-sleep-inducing peptide


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  Peptide Sciences Core Peptides
Cost per milligram
$5.5 - $6.9
$10.00 $8.20
Purity
99.88%
98.7% 98.5%
Certified Endotoxin-safe
Yes
No No
Independently Tested
Yes
No No

 

Peptide Partners Manufacturer Id: SH07

Batch Id:  DS20250820

 

Overview

(For educational purposes only)

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide that has been investigated for its role in the regulation of sleep, stress response, and neuroendocrine modulation. Discovered in the 1970s, DSIP continues to attract research interest due to its influence on delta-wave sleep, potential stress-protective effects, and unexplained distribution and biosynthesis.

Molecular Identity and Structure

CAS Number: 62568-57-4
Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
Molecular Formula: C35H48N10O15
Molecular Weight: 848.8–849.0 g/mol
PubChem CID: 68816
Discovery Year: 1974 (by G. Schoeneberger and M. Monnier)[1][2]
Broad Category: Endogenous neuropeptide; sleep-promoting/regulatory peptide[3][1]

Biochemistry and Distribution

DSIP is an amphiphilic nonapeptide that occurs in both free and bound forms throughout the hypothalamus, limbic system, pituitary gland, and various peripheral organs (including the gut and pancreas). In the pituitary, it colocalizes with several peptide and non-peptide hormones, such as ACTH, MSH, and TSH. Notably, DSIP is commonly detected in plasma and secretory cells of the gastrointestinal tract, often co-localized with glucagon.[4][1][3]

Biological Functions

DSIP's primary function is linked to the promotion of delta-wave (SWS, "deep" non-REM) sleep in mammals, as indicated by its name and classical pharmacological experiments. Research has shown that DSIP can modulate sleep patterns, regulate circadian rhythms, influence hormone levels (notably reducing corticotropin, increasing growth hormone, and other stress axis hormones), and affect neuronal transmitter activity. The peptide also demonstrates stress-protective, anti-seizure, and immunomodulatory effects in various animal models.[2][1]

DSIP's action in the brain seems to be associated with NMDA receptor activity, and it may interact with the MAPK cascade, and is possibly homologous to the glucocorticoid-induced leucine zipper protein GILZ, implicating it in stress physiology.[1]

Stability and Metabolism

DSIP is characterized by low molecular stability in vitro, exhibiting a half-life of about 15 minutes due to rapid enzymatic degradation. It is hypothesized that in vivo, DSIP is stabilized by carrier proteins or is stored as a component of a larger precursor molecule, though the gene coding for its precursor has not yet been conclusively identified in mammals.[4][1]

Potential Clinical Roles and Research

DSIP's sleep, anti-stress, and neuroendocrine effects have prompted exploration of its therapeutic potential in sleep disorders, pain syndromes, epilepsy, and some neuroendocrine and stress-related illnesses. However, efficacy and mechanisms in human clinical trials remain insufficiently defined, and DSIP is primarily considered an experimental neuropeptide at present.[5][3]

Conclusion

Delta Sleep-Inducing Peptide is a unique, endogenous neuropeptide notable for its sleep-promoting and neuroendocrine effects. Despite some gaps in understanding regarding its synthesis and signaling pathways, DSIP remains of strong research interest for roles in sleep regulation, stress physiology, and neuroendocrine modulation. Clinical application is experimental and awaits more definitive research to elucidate its mechanisms, therapeutic value, and long-term safety profile.[3][2][5][1][4]

 

  1. https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide       

  2. https://www.biosyn.com/tew/deltasleep-inducing-peptide-or-dsip.aspx   

  3. https://www.sciencedirect.com/topics/neuroscience/delta-sleep-inducing-peptide    

  4. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6478191.htm   

  5. https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.03693.x  

  6. https://www.peptide.co.jp/pdf/msds/en/4054_20231220_en.pdf 

  7. https://pubchem.ncbi.nlm.nih.gov/compound/dsip 

  8. https://pubchem.ncbi.nlm.nih.gov/compound/68816 

  9. https://modernpeptides.com/product/dsip/ 

 

Storage Instructions:

All of our manufacturing partners produce peptides using the Lyophilization (Freeze Drying) process, ensuring products maintain stability for shipping and storage for 6+ months. 

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer-term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.

 

Third-party testing

Peptide Partners is committed to providing high-purity peptides at wholesale prices by frequently auditing its manufacturing partners using third-party laboratories. Independent analysis is vital to ensuring the quality and authenticity of your research peptides. Never trust a supplier that doesn't submit to third-party testing. Never trust a certification that cannot be independently verified. All of the certificates that we provide can be validated on the third-party laboratory's website. 

Each product description contains a Manufacturer ID corresponding to the producer of that product. The table below contains the most recent third-party analyses for all manufacturers and peptides listed on Peptide Partners. 

Current Purity certifications

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 Peptide Manufacturer Date Purity Laboratory
Humanin WF03 2025-09-19 99.92% BioRegen View File
MOTS-c WF03 2025-09-19 99.87% BioRegen View File
DSIP SH07 2025-09-19 99.88% BioRegen View File
SS-31 WF03 2025-09-19 99.70% BioRegen View File
CJC/Ipamorelin WF03 2025-09-11 99.84% TrustPointe View File
BPC-157 WF03 2025-09-05 99.99% TrustPointe View File
Sermorelin WF03 2025-08-27 99.84% BioRegen View File
Tesamorelin WF03 2025-08-22 99.10% TrustPointe View File
CJC-1295 ND WF03 2025-08-20 99.43% TrustPointe View File
Semaglutide EJ12 2025-08-20 99.34% TrustPointe View File
Ipamorelin WF03 2025-08-15 99.64% TrustPointe View File
GHK-Cu SH07 2025-08-09 99.73% BioRegen View File
Tirzepatide EJ12 2025-08-08 99.41% TrustPointe View File
NAD+ SH07 2025-07-31 99.76% BioRegen View File
VIP SH07 2025-07-31 99.42% BioRegen View File
Retatrutide SH07 2025-07-25 99.42% TrustPointe View File
BPC/TB500 SH07 2025-07-17 99.52% TrustPointe View File
TB500 (TB4) SH07 2025-07-17 99.68% TrustPointe View File
Cagrilinitide EJ12 2025-04-17 99.64% TrustPointe View File

Current Endotoxin Certifications

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 Peptide Manufacturer Date USP<85> Conformation Laboratory
Humanin WF03 2025-09-19 Conforms BioRegen View File
MOTS-c WF03 2025-09-19 Conforms BioRegen View File
DSIP SH07 2025-09-19 Conforms BioRegen View File
SS-31 WF03 2025-09-19 Conforms BioRegen View File
CJC/Ipamorelin WF03 2025-09-03 Conforms TrustPointe View File
BPC-157 WF03 2025-09-03 Conforms TrustPointe View File
Bacteriostatic Water SH07 2025-08-27 Conforms BioRegen View File
Tesamorelin WF03 2025-08-20 Conforms TrustPointe View File
CJC-1295 ND WF03 2025-08-20 Conforms TrustPointe View File
Sermorelin WF03 2025-08-20 Conforms TrustPointe View File
Semaglutide EJ12 2025-08-20 Conforms TrustPointe View File
Ipamorelin WF03 2025-08-11 Conforms TrustPointe View File
GHK-Cu SH07 2025-08-08 Conforms TrustPointe View File
Tirzepatide EJ12 2025-08-04 Conforms TrustPointe View File
NAD+ SH07 2025-07-29 Conforms TrustPointe View File
KPV SH07 2025-07-29 Conforms TrustPointe View File
VIP SH07 2025-07-29 Conforms TrustPointe View File
Retatrutide SH07 2025-07-24 Conforms TrustPointe View File
BPC/TB500 SH07 2025-07-17 Conforms TrustPointe View File
TB500 (TB4) SH07 2025-07-17 Conforms TrustPointe View File

Current Sterility Certifications

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 Product Manufacturer Date USP<71> Pass/Fail Laboratory
Bacteriostatic Water SH07 2025-09-09 Pass TrustPointe View File
Meta-Z DF05 2025-08-26 Pass TrustPointe View File

Verifiable certificates

When obtaining research peptides, it is essential to validate the authenticity of the Certificate of Analysis (COA). Certificate fraud runs rampant throughout the research peptide supply community. The two most common forms are doctored images and stolen certificates. You can check for these two by making sure the third-party laboratory's website shows that the certificate belongs to the supplier and the values haven't been doctored. TrustPointe Analytics provides a few simple rules for verification:

When reviewing a COA, the first thing that should be done is to look for a way to verify that the COA is legitimate – either a link, key, or QR Code. That should take you to the laboratory’s website, not a third party website. If you follow the link and it does not take you to the laboratory’s website (URL), it is likely falsified. Finally, verify that the information on the COA provided matches the COA on the laboratory’s website. People who falsify COAs cannot access the laboratory’s website, so they are unable to alter the original COA.

Beware of fraudulent laboratories

Not only must one remain vigilant about potentially fraudulent certificates, one must also be aware that there are third-party laboratories whose results cannot be considered reliable or scientifically valid. Unfortunately, there is significant evidence to suggest that one of the most popular third-party testing labs does not use scientifically sound methodologies and, in some cases, has fabricated results. There isn't an easy remedy for this problem, but when labs are particularly bad, there tend to be a lot of discussion threads on various social platforms.

Interpreting Endotoxin Results (via TrustPointe)

Our friends at TrustPointe have provided the following detailed explanation to help interpret the results of the endotoxin testing.

We use the Charles River Endosafe PTS system to test for bacterial endotoxins following USP <85> guidelines:

  • USP <85> Bacterial Endotoxin Result: <x.xx EU/mL
    Because it’s reported as “<x.xx” this indicates the test did not detect endotoxin above the detection limit of the cartridge.
  • If a result is above the limit of detection of the cartridge, it will be reported as a number (without the "<").

The following are suitability parameters that verify the system was working properly and the sample prep dilution is appropriate for accurate results. Peptides often interfere with endotoxin detection due to their tendency to bind or mask endotoxins, which can lead to inaccurate low results. To overcome this, samples are typically tested at a large dilution to reduce matrix interference and ensure reliable recovery and detection in compliance with USP <85>.  If the dilution is not correct, the run will fail suitability and we'll need to adjust the dilution to ensure accurate results. We provide the suitability data to customers for transparency and so they can be confident in the results.

USP <85> Sample CV %:

  • CV stands for coefficient of variation, a measure of repeatability.
  • For our lab, CV has to be <25% or the result to be considered valid

USP <85> Spike CV %:

  • This refers to the precision of the positive control (spiked sample).
  • Again, for our lab CV has to be <25% or the result to be considered valid

USP <85> Spike Recovery

  • This tells us how much of the known endotoxin spike was recovered from your sample.
  • The acceptable range is 50–200% per USP <85>
NOT SUITABLE FOR HUMAN CONSUMPTION – INTENDED FOR RESEARCH ONLY

Thank you for choosing Peptide Partners.

NOTICE: All information provided above is strictly intended for educational and informational purposes. Our products are designed for research use solely and are not approved for human consumption. Please refrain from any form of ingestion.

By making a purchase from Peptide Partners, you acknowledge that you are acquiring Research Chemicals. Our products are exclusively intended for laboratory research purposes.

It is imperative that only qualified and licensed professionals handle this product. Under no circumstances should it be utilized as a drug, agricultural or pesticide product, food additive, or household chemical. Misrepresentation of this product for such purposes is strictly prohibited by law. All content on our website is provided for educational use exclusively. Any form of introduction into the human or animal body is illegal.

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